egf signaling pathway
| PAG Title | egf signaling pathway |
| PAG ID | WAG000230 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kise cytoplasmic domain, a single transmembrane domain and an extracellular domain involved in EGF binding and receptor dimerization. Inhibitors of the EGF receptor are being pursued as potential cancer therapies and EGF may stimulate wound healing. Mutation of the EGF receptor has been associated with cancer in humans. The proliferative effects of EGF are sigled through several pathways. Binding of EGF results in EGF receptor dimerization, autophosphorylation of the receptor, and tyrosine phosphorylation of other proteins. The EGF receptor activates ras and the MAP kise pathway, ultimately causing phosphorylation of transcription factors such as c-Fos to create AP-1 and ELK-1 that contribute to proliferation. Activation of STAT-1 and STAT-3 transcription factors by JAK kises in response to EGF contributes to proliferative sigling. Phosphatidylinositol sigling and calcium release induced by EGF activate protein kise C, another component of EGF sigling. Crosstalk of EGF sigling with other pathways make the EGF receptor a junction point between sigling systems. |
| Species | Homo sapiens |
| nCoCo Score | 4,065 |
| Base PAG ID | WAG000230 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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